Alzheimer's DiseaseChronic Pain

Does Prevagen Really Work?

People with chronic pain often complain of difficulty with memory and cognition.

Chronic pain, sleep deprivation, depression, medication side effects, and a host of other reasons often effect cognition in chronic pain patients.
There are many over the counter supplements that claim to improve cognition. Prevagen is a popularly advertised supplement that claims to do this but, does Prevagen really work?

This article will try to answer that question by explaining what it is, how it is theorized to work, in what conditions it may be used for, side effects, and how it is dosed. I think you will find the information useful in order that you can make an informed decision as to whether Prevagen is right for you.


What Is Prevagen?

Prevagen is the trade name for a nootropic supplement (supplements that can effect higher order mental function) that is commonly seen advertised in the media. The active ingredient in it is called apoaequorin.

The substance was originally discovered in a species of jellyfish.
When combined with calcium it results in a chemical luminescence emitted by the jellyfish (the production of blue light). Researchers later connected the protein with brain health.

Just how that connection was discovered I have been unable to elucidate in the research I did for this article.


How Does It Work Chemically?

There is a “natural” and “unnatural” loss of brain cells (called neurons) with aging.  In the “natural” loss of neurons there is the death of thousands of neurons each day by a calcium mediated mechanism.

It would appear that excess calcium inside the neuron has a destructive influence.  The brain “cleans itself up” or “prunes itself” by this mechanism.

Furthermore, a reduction of calcium in the chemically vital area of the neuron called the synapse (the space between two connected neurons) also results in a reduction of nerve function.

calcium inside the neuron

So, with age, there is a deterioration of structure and function of the brain mediated by calcium. It also stands to reason that the entire brain does not deteriorate uniformly.

Certain areas (such as the Hippocampus which is involved with memory) deteriorate more rapidly than other areas of the brain.

The “unnatural” mechanisms for neuron death (such as in Alzheimer’s disease) are beyond the scope of this article and will not be discussed at this time.

The proposed mechanism for how Prevagen works is by stabilizing the calcium of the neuron. The levels inside would be reduced and the synaptic levels would be increased.

As the brain possesses a “barrier” to large molecules (called the “blood-brain barrier”), supplementation with Prevagen does not result in immediate improvement in function.
Supplementation must continue for at least 4 weeks before actual improvement in memory is observed.

What Specific Brain Functions Is Prevagen Useful For?

The manufacturers of Prevagen (Quincey Bioscience) claim that it has the following effects:

  • Improves Word Recall
  • Improves Learning
  • Reduces Forgetfulness
  • Improves Executive Function (problem solving and reasoning)
  • Improves Sleep

Quincey Bioscience has several “studies” that they have performed to make these claims.  Unfortunately, the studies were never published in the usual “peer reviewed” format that new advances in science are usually evaluated in.

When a new treatment is developed, the most credible way to evaluate it is to have others review the data and “weigh in” with their opinions.  This is the “peer review” process.

Even though the process is not perfect, it is the best way to objectively evaluate a new therapy prior to any claims being made.  Quincey Bioscience has not had Prevagen peer reviewed.

What Are The Side Effects That Are Possible With Prevagen?

The Journal of Food and Chemical Toxicology published an article in 2013 on the toxic effects of high doses of apoaequorin force fed to rats.  With doses many times higher than is offered in the supplement Prevagen, the rats did not develop any major side effects.

Furthermore, no rats died from these huge doses.

This report was in response to the side effects that thousands of people have reported using Prevagen.  Nausea, seizures, vomiting, dizziness, chest pain, stroke, and worsening of Multiple Sclerosis symptoms have been reported. 

There are even more symptoms that people claim to have experienced taking Prevagen.

It must be remembered that the occurrence of a symptom with the use of any substance does not necessarily prove that the substance caused it. It shows association but not necessarily causation.

The lay public is often unaware of this important distinction.

However, an association does not exclude that some of the symptoms could have been caused by thePrevagen.  It seems that more studies are needed to “flush out” the truth in this case.

You should also know that Quincey Bioscience has been notified by the Food and Drug Administration that they may be in violation of supplement guidelines.  I have included a link for you of the actual communication with the FDA October 16, 2012:

Inspections, Compliance, Enforcement, and Criminal Investigations

How Is Prevagen Dosed?

Prevagen is commercially available without a prescription being needed. It is available in 10 mg, 20 mg, and 40 mg doses.

Prevagen is taken once a day for at least 30 days before a positive effect can be expected.
Prevagen is not cheap.

The product itself has none of the usual allergic inducing additives (gluten, peanuts, etc). It is taken by mouth on an empty stomach before the first meal of the day.

There is hope…

I have reviewed some of the “science” behind Prevagen, how it works, what it can be used for, side effects, and dosing.

Though Prevagen seems safe enough, I cannot give a recommendation to use the supplement as more information is needed on its effectiveness and side effects.
This product seems to be one of the many supplements foisted on the American people by slick marketing with a minimum of scientifically provable claims.

You should know that the whole field of “nootropics” is a very intense area of scientific investigation at the present time. The field of Neuroscience is looking for the “magic bullet” that will enhance your memory and intellect.

I believe it is only a matter of time until a real substance is identified and marketed to the American public.

I hope you have found this brief discussion of Prevagen useful. If you have any questions please comment.

Wishing you much joy and healing.


Related Articles


  1. Hi there just wanted to give you a quick heads up.
    The words in your post seem to be running off the screen in Ie.
    I’m not sure if this is a formatting issue or something to do with web browser compatibility but I figured I’d post to let you know.
    The design look great though! Hope you get the issue resolved soon. Kudos

  2. Today, I went to the beachfront with my kids.
    I found a sea shell and gave it to my 4 year old daughter
    and said “You can hear the ocean if you put this to your ear.”
    She put the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear.
    She never wants to go back! LoL I know this is
    entirely off topic but I had to tell someone!

  3. I loved as much as you’ll receive carried out right here.
    The sketch is attractive, your authored material stylish.
    nonetheless, you command get bought an edginess over that you wish be delivering the following.
    unwell unquestionably come further formerly again since exactly the same nearly a lot
    often inside case you shield this increase.

  4. I am sure this post has touched all the
    internet viewers, its really really fastidious
    article on building up new web site.

  5. When I initially commented I clicked the “Notify me when new comments are added” checkbox and now
    each time a comment is added I get several emails with the same comment.
    Is there any way you can remove me from that service?
    Bless you!

  6. Heya i am for the first time here. I found this board
    and I find It truly useful & it helped me out much. I hope to
    give something back and help others like you helped me.

  7. When some one searches for his necessary thing,
    thus he/she needs to be available that in detail, therefore that thing is maintained over here.

  8. You made some really good points there. I checked
    on the web to find out more about the issue and found most people will go along with
    your views on this web site.

  9. Hi there, You’ve done an incredible job. I’ll certainly digg it and personally recommend to
    my friends. I am sure they’ll be benefited from this web

  10. Its like you read my mind! You appear to know a lot about this, like you wrote the book in it or something.
    I think that you can do with some pics to drive the
    message home a bit, but instead of that, this is great blog.

    A fantastic read. I’ll definitely be back.

  11. Write more, thats all I have to say. Literally, it
    seems as though you relied on the video to make your point.
    You obviously know what youre talking about, why throw away your intelligence on just posting videos
    to your blog when you could be giving us something enlightening to read?

  12. Hey there! Do you use Twitter? I’d like to follow you if that
    would be okay. I’m absolutely enjoying your blog and look
    forward to new posts.

  13. For latest information you have to pay a visit web and on web I found this site
    as a most excellent web page for most up-to-date updates.

  14. Does your website have a contact page? I’m having trouble locating it but, I’d like to shoot you
    an e-mail. I’ve got some ideas for your blog you might be interested in hearing.

    Either way, great website and I look forward to
    seeing it develop over time.

  15. I read this piece of writing fully on the topic of the comparison of most recent and previous technologies, it’s amazing article.

  16. Hi, I do believe this is a great web site. I stumbledupon it ;
    ) I’m going to come back once again since I bookmarked it.
    Money and freedom is the greatest way to change,
    may you be rich and continue to guide other people.

  17. I’ve learn a feew good stuff here. Certainly value bookmarking for revisiting.
    I wonder how so muc effoort you put to create this kind of excellent infdormative web site.

  18. Right here is the right web site for anybody who
    wants to find out about this topic. You realize so much its almost tough to argue
    with you (not that I actually would want to…HaHa).
    You definitely put a fresh spin on a topic which has
    been discussed for decades. Wonderful stuff, just great!

  19. I know this if off topic but I’m looking into starting my
    own blog and was wondering what all is required to get setup?
    I’m assuming having a blog like yours would cost a pretty
    penny? I’m not very internet savvy so I’m not 100% positive.
    Any suggestions or advice would be greatly appreciated. Many thanks

  20. I’d like to thank you for the efforts you have put in penning this website.
    I really hope to view the same high-grade blog posts from you later on as well.
    In truth, your creative writing abilities has encouraged me to get my own,
    personal site now 😉

  21. I think this is among the most vital info for me.
    And i am glad reading your article. But want to remark on few general things, The site style is great, the articles is really nice : D.
    Good job, cheers

  22. I’m not sure why but this blog is loading incredibly slow for me.
    Is anyone else having this issue or is it a issue on my end?
    I’ll check back later on and see if the problem still exists.

  23. Hmm it appears like your site ate my first comment
    (it was super long) so I guess I’ll just sum it up what I had written and say, I’m thoroughly enjoying your
    blog. I too am an aspiring blog blogger but I’m still new to the whole thing.
    Do you have any recommendations for newbie blog writers?
    I’d certainly appreciate it.

  24. I’ve been surfing on-line more than three hours these days, but I by no
    means found any interesting article like yours. It is beautiful worth enough for
    me. In my view, if all site owners and bloggers made good
    content material as you probably did, the web might be a lot more helpful than ever before.

  25. Hmm is anyone else encountering problems with the images on this
    blog loading? I’m trying to figure out if its a problem on my end
    or if it’s the blog. Any feedback would be greatly appreciated.

  26. I loved as much as you will receive carried out right here.
    The sketch is attractive, your authored material stylish. nonetheless, you command get got an edginess over that you wish be delivering the following.
    unwell unquestionably come more formerly again as exactly the same nearly a lot often inside case you shield this hike.

  27. Unquestionably believe that which you said. Your favourite reason appeared to
    be on the net the easiest thing to understand of.
    I say to you, I definitely get irked while people consider
    issues that they just do not recognize about. You managed to hit the nail upon the
    top as well as outlined out the whole thing without having
    side effect , other people could take a signal. Will likely be back to
    get more. Thank you

  28. Good way of explaining, and nice article to obtain information about
    my presentation focus, which i am going to deliver in institution of
    higher education.

  29. If some one desires expert view concerning blogging afterward i propose him/her to go
    to see this web site, Keep up the good job.

  30. of course like your web site but you need to test the spelling on quite a few
    of your posts. Many of them are rife with spelling problems and I to find it very bothersome to inform the reality nevertheless
    I’ll surely come back again.

  31. Undeniably believe that which you stated. Your favorite justification appeared to be on the web the easiest factor to
    have in mind of. I say to you, I certainly get annoyed while
    folks consider concerns that they just don’t realize about.

    You controlled to hit the nail upon the top
    and defined out the whole thing without having side-effects , people can take a signal.
    Will likely be again to get more. Thank you

  32. I’m really enjoying the design and layout of your site.
    It’s a very easy on the eyes which makes it much more pleasant for me to come here and
    visit more often. Did you hire out a designer to create your theme?
    Outstanding work!

  33. You should take part in a contest for one of the highest quality sites on the web.

    I am going to highly recommend this blog!

  34. 광주콜걸
    Everything is very open with a precise description of the challenges.
    It was definitely informative. Your website is useful.
    Thank you for sharing!

  35. Hi there! This is my first visit to your blog!
    We are a collection of volunteers and starting a new project in a community in the same niche.
    Your blog provided us beneficial information to work on. You have done a extraordinary job!

  36. I have been surfing online more than 3 hours today, yet I
    never found any interesting article like yours. It’s pretty worth enough for me.

    In my view, if all site owners and bloggers made good content as you did, the web will be much more useful
    than ever before.

  37. Thanks for the good writeup. It if truth be told was
    once a amusement account it. Glance advanced to far introduced agreeable from you!
    By the way, how could we be in contact?

  38. Just want to say your article is as astonishing. The clearness on your publish is simply great and i can think you are
    a professional on this subject. Fine along with your permission allow me to clutch your RSS feed to stay updated with impending post.
    Thank you one million and please carry on the enjoyable work.

  39. It is in reality a nice and useful piece of info.
    I am satisfied that you shared this useful info with us.
    Please stay us up to date like this. Thanks for

  40. Hi there all, here every one is sharing such familiarity, so it’s pleasant to read this
    web site, and I used to visit this web site all the time.

  41. I know this if off topic but I’m looking into starting my own blog and
    was wondering what all is needed to get set up?
    I’m assuming having a blog like yours would cost a pretty penny?

    I’m not very internet smart so I’m not 100% certain.
    Any recommendations or advice would be greatly appreciated.


  42. Somebody necessarily help to make significantly
    posts I’d state. This is the first time I frequented
    your web page and thus far? I surprised with the analysis you
    made to make this particular put up incredible.

    Magnificent process!

  43. Good day! This is my 1st comment here so I just wanted to give a quick shout out and tell
    you I truly enjoy reading through your posts. Can you suggest any other blogs/websites/forums that deal with the
    same topics? Thank you so much!

  44. I am really enjoying the theme/design of your weblog. Do you ever run into any
    internet browser compatibility problems? A number
    of my blog audience have complained about my website not
    operating correctly in Explorer but looks great in Safari.
    Do you have any tips to help fix this issue?

  45. I’m really impressed with your writing skills and also with the
    layout on your blog. Is this a paid theme or did you modify it
    yourself? Either way keep up the nice quality writing, it is rare to
    see a nice blog like this one nowadays.

  46. It’s in fact very complicated in this busy life to listen news on TV,
    so I only use web for that reason, and get
    the most recent information.

  47. Hey there I am so delighted I found your webpage, I really found
    you by accident, while I was browsing on Askjeeve for something else, Anyhow I am here now and would just like to say kudos for a incredible
    post and a all round exciting blog (I also love the theme/design),
    I don’t have time to read it all at the minute but I have saved it and also included your RSS feeds, so when I have time I will be back to read much more, Please do keep up the superb work.

  48. Great goods from you, man. I have understand your stuff previous to and you are just
    extremely fantastic. I actually like what you’ve acquired here, really like what you’re stating and the way in which you say it.

    You make it enjoyable and you still take care of to keep it smart.
    I cant wait to read far more from you. This is actually a terrific web site.

  49. I’d like to thank you for the efforts you’ve put
    in penning this website. I’m hoping to view the same high-grade
    content from you in the future as well. In truth, your creative writing abilities has motivated me to get my own website now ;

  50. Hey! This post couldn’t be written any better! Reading through this post reminds me of
    my good old room mate! He always kept talking about this.

    I will forward this article to him. Pretty sure he
    will have a good read. Thanks for sharing!

  51. Hey There. I discovered your weblog the use of msn. This is a very well written article.
    I will be sure to bookmark it and come back to learn more of your useful info.
    Thank you for the post. I will definitely comeback.

  52. Your style is unique in comparison to other folks I have read
    stuff from. Thanks for posting when you have the opportunity, Guess I’ll just book mark this web site.

  53. I’ll immediately grasp your rss feed as I can not find your email subscription hyperlink or newsletter service.

    Do you’ve any? Please let me know in order that I may subscribe.

  54. I think the admin of this website is genuinely working hard in support of his web page, because here every stuff is quality based information.

  55. Hi there, every time i used to check webpage posts here in the early hours in the morning,
    because i love to find out more and more.

  56. Terrific article! That is the type of information that should be shared around
    the internet. Disgrace on Google for now not positioning this submit higher!
    Come on over and discuss with my website .
    Thanks =)

  57. Thanks for ones marvelous posting! I truly enjoyed reading it, you will be a great author.
    I will be sure to bookmark your blog and may come back in the foreseeable future.
    I want to encourage you to definitely continue your great work, have a nice afternoon!

  58. Somebody essentially lend a hand to make significantly articles I would state. This is the very first time I frequented your web page and thus far? I surprised with the research you made to make this actual publish incredible. Fantastic job!

  59. certainly like your web site however you have to test the spelling on several of your posts.
    A number of them are rife with spelling issues and I to find it very troublesome to inform the reality then again I
    will certainly come back again.

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button

Adblock Detected

Please consider supporting us by disabling your ad blocker