Bulging DiscChronic PainDisc DegenerationFibromyalgia

Tylenol Side Effects

Have You Considered This?

So if a medicine is over-the-counter (OTC) it must be safe, right?  Well, when you consider Tylenol side effects with the potential liver toxicity, kidney toxicity, skin toxicity, toxicity to the fetus, overdoses, emergency room visits, and hospitalizations all related to this substance, you might wonder how it ever became legal.

The American generic name for Tylenol is acetaminophen.  Canada, Japan and a few other countries with close ties to the U.S. also use the same generic name.

However, the predominately used international name is paracetamol.  The chemical name “American style” is N-acetyl-p-aminophenol (also called APAP).  The name acetaminophen is a shortened hybrid of the chemical name.


Tylenol is the number one used OTC pain medicine in the U.S.  This article will concentrate on the potential Tylenol side effects.  But first, some brief history…

What is The History Of Tylenol?

The development of this substance occurred in 1852 by Charles Gerhardt, a French chemist.  It was called acetanilide.

Charles Gerhardt

In 1899 Karl Morner (a German scientist) discovered that acetanilide was metabolized in the liver to the active compound acetaminophen.

Karl Morner

The actual production of the direct compound came years later.  However, widespread use did not occur until McNeil Laboratories (headquartered in Philadelphia, Pennsylvania at the time) marketed APAP with butabarbital as a prescription pain relieving medicine in 1953. 

Shortly thereafter, Children’s Tylenol was released on the market by the same company (in 1955).  It was offered as a safer alternative to aspirin for children.

In 2005 over 28 billion doses of Tylenol (or Tylenol combined with another medicine) were used by Americans.

all of Tylenol

How Does Tylenol Work?

One would think that for the long period of time APAP has been around we would have a detailed understanding of how it works…we don’t.  We do know that it works on a category of chemical messengers called prostaglandins.

These local hormones modulate the transmission of pain signally and the production of a fever response in illness or injury.  By blocking the prostaglandins, pain and fever can be blocked.  This puts APAP in a category of medicines called NSAIDs (or non-steroidal anti-inflammatory medicines).

Although it is in the same class as aspirin and ibuprofen (Motrin), APAP does not affect the prostaglandin system in the same way. A very big difference is that the formation of stomach ulcers is not seen with APAP.

Furthermore, the clotting problems seen with aspirin and ibuprofen do not occur with APAP.  All good news for APAP (and McNeil Laboratories).

What Is Tylenol Good For?

Important Note

APAP is a very good medicine for pain and fever relief.  The following is a partial listing of the conditions APAP may be good for:

How Is Tylenol Dosed?

Here is a few table that outlines the proper Pediatric dosing for APAP:


Remember that APAP is taken every 4 to 6 hours as needed.

What Are The Potential Side Effects Of Tylenol?

There are few acute side effects to APAP (other than what might be expected in an overdose).  A good “rule of thumb” to follow with side effects is, “any negative change in condition after starting APAP requires immediate stopping of the medicine and evaluation by a licensed primary care practitioner or physician.”

People with pre-existing liver or kidney disease should only take APAP under the direct supervision of a licensed primary care practitioner or physician.  That includes a history of alcoholism, drug abuse, and Hepatitis (any type).

You must also be very aware of the chronic medications you are be taking and any interaction that may occur with APAP.  The supervision of your primary care practitioner or physician is essential to properly evaluate drug interactions.

APAP has over 160 different medications that it may interact with.

Special conditions such as pregnancy and nursing are also times to be very careful taking APAP.  There have been reports of a higher incidence of Asthma in children of mothers having taken APAP during their pregnancy.

The following table reviews potential serious side effects:


To avoid a potential overdose or serious side effects consider the following:

potential overdose or serious side effects of tylenol

Summary Remarks

I have reviewed Tylenol side effects as well as its history, mechanism of action, and indications.  It is wisdom to remember that any medicine that has an effect will always have side effects.

There is no possible way to take a medicine without risk.

By following the basic information and dosing guidelines outlined in this monograph, Tylenol can be taken safely.  It is a very effective pain reliever (4 regular strength 325 mg Tylenol tablets is equal to 4 mg of morphine in pain relief).

I trust this article has been informative and helpful.  Please leave me a comment or question in the box below.

Wishing you joy and good health.


Related Articles


  1. Hello there! I know this is kinda off topic but I was
    wondering which blog platform are you using for this website?
    I’m getting tired of WordPress because I’ve had issues with hackers and I’m looking at alternatives
    for another platform. I would be fantastic if you could point me in the direction of a good platform.

  2. Write more, thats all I have to say. Literally, it seems
    as though you relied on the video to make your point.
    You clearly know what youre talking about, why throw away your intelligence on just posting videos to your blog
    when you could be giving us something enlightening to read?

  3. I feel that is one of the such a lot vital information for me.
    And i am glad studying your article. But wanna statement on some common issues, The website style
    is ideal, the articles is in point of fact great : D. Excellent task, cheers

  4. If some one needs expert view on the topic of blogging
    and site-building then i advise him/her to visit this weblog, Keep up the fastidious

  5. Excellent post. I was checking continuously this blog and
    I’m impressed! Very helpful information specially the last
    part 🙂 I care for such info much. I was looking for this particular
    info for a very long time. Thank you and good luck.

  6. Excellent blog! Do you have any suggestions for aspiring writers?
    I’m hoping to start my own site soon but I’m a little lost on everything.
    Would you suggest starting with a free platform like WordPress or go
    for a paid option? There are so many choices out there that I’m totally confused
    .. Any tips? Appreciate it!

  7. Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point.
    You obviously know what youre talking about, why throw away your
    intelligence on just posting videos to your weblog when you
    could be giving us something informative to

  8. Usually I do not learn post on blogs, however I wish to
    say that this write-up very compelled me to try and do it!
    Your writing taste has been amazed me. Thanks, quite great post.

  9. I think the admin of this web page is really working hard
    in support of his site, because here every material is quality based information.

  10. I do not even know how I ended up here, but I thought this post was great.
    I don’t know who you are but certainly you’re going to a famous blogger if
    you are not already 😉 Cheers!

  11. I want to express some appreciation to this writer for bailing me out of this particular circumstance.
    Right after surfing around throughout the online world and finding things that were not productive, I
    thought my life was gone. Living without the solutions to the problems you have resolved as a result of your entire review is a
    crucial case, and the kind which might have in a negative way damaged my career
    if I had not discovered your site. That skills and kindness
    in dealing with all the details was excellent. I don’t know what I
    would have done if I hadn’t encountered such a thing like this.
    I am able to at this time relish my future. Thank you so
    much for this professional and amazing guide. I won’t hesitate to suggest your site to anyone who would
    need guidance on this situation.

  12. I think the admin of this web site is in fact working hard for his
    site, because here every information is quality based

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button

Adblock Detected

Please consider supporting us by disabling your ad blocker